TLR4 and colonic neoplasm: Using the Cancer Predisposition Gene Database [39], 24 human orthologues with corresponding mouse CR DEGs were identified as cancer predisposition genes (CPGs), genes in which inherited mutations in confer increased cancer risk: colon cancer CPGs (GSTM1, MBL2, RBBP8) and gastric cancer CPGs (NOS2, PSCA, TLR4).