Of these genes, several of our hypothesized duodenal key cancer-risk or immune modulators were also regulated in the liver: suppressed immune and inflammatory response (Stat1, Ifit1, Cxcl10), activated metabolism including glutathione (Ppara, Gsta2), tumor suppressor loss (Arntl), and activated oncogenes (Fkbp5, Rab30, Mt2). The gene discussed is BMAL1; the disease is cancer.