It determined activated DEGs related to tumor cell signaling associated with increased proliferation, transcription, oncogenesis, migration, and invasion: CBLC, POLB, ATF1, TFEB, ACVR1B, LAMC2, GSK3B, PHF6, MAP3K8, ARIDIA. Our study also demonstrated CR-induced Lamc2 overexpression. Here, POLB is linked to neoplasm.