Dysbiosis (an imbalanced gut microflora ecosystem) conditions lead to activation of MAPK (mitogen-activated protein kinases) pathway and nuclear translocation of NF-κB that leads to the secretion of different pro-inflammatory cytokines such as IL-8 and nitric oxide, which consequently leads to the occurrence of IBD and colorectal cancer. Here, CXCL8 is linked to colorectal cancer.