Most of the driver events inhibit the action of tumour suppressor functions on the cell cycle (p16INK4A; p53), survival (PTEN), WNT signalling (protocadherinFAT1; LIM domain-containing protein AJUBA; NOTCH1), and epigenetic regulation (histone-lysine N-methyltransferases KMT2D and NSD1). The gene discussed is CDKN2A; the disease is neoplasm.