Furthermore, various secretions (TGF-beta, vascular endothelial growth factor (VEGF), IL-6, IL-10, prostaglandin E2 (PGE2), and chemokines) by the M2 macrophages act to promote tumour metastasis and Treg expansion with concomitant suppression of effector T cell activity [67]. The gene discussed is VEGFA; the disease is neoplasm.