The dysregulation of this auto-regulatory loop could be also due to the abnormal expression of SIRTs in psoriasis, with the downregulation of SIRT1, SIRT2, SIRT3, SIRT4, and SIRT5 and upregulation of SIRT6 and SIRT7 in skin lesions skin, as previously reported [44,45]. Here, SIRT4 is linked to psoriasis.