Regarding inflammatory cytokines, four meta-analyses of serum or plasma samples from BD patients invariably reported significantly increased levels of TNF-α and sIL-2R; IL-4, IL-6, IL-1RA, sIL-6R and TNFR1 levels were significantly increased in two meta-analyses; IL-10 levels were significantly increased in one meta-analysis [123,134,135,136]. This evidence concerns the gene IL6R and Behcet disease.