SIRT3 and pulmonary fibrosis: Third, overexpression of SIRT3 using either genetic or pharmacologic approaches mitigates oxidant-induced fibroblast profibrotic signaling and AEC mtDNA damage and apoptosis in vitro as well as bleomycin-induced lung fibrosis in vivo [32,33,34,35,37,38] and promotes lung fibrosis resolution in aged mice [35].