Our group has established a causal role for the recruitment of pro-fibrotic monocyte-derived alveolar macrophages (Mo-AMs) in the development of both bleomycin- and asbestos-induced lung fibrosis, but the role of SIRT3 in modulating recruitment of Mo-AMs is unclear [40,41,42]. Here, SIRT3 is linked to pulmonary fibrosis.