In another independent study investigating the mechanism behind such anti-cancer activity, the result pointed out that apo-10′-lycopenoic acid may increase NRF2, HO-1, NAD(P)H dehydrogenase (quinone 1), GSTs, GCL and GSH levels in BEAS-2B cells, suggesting that lycopene may exhibit both anti-carcinogenic and antioxidant activity via NRF2 activation and induction of detoxifying enzymes [66]. Here, NFE2L2 is linked to cancer.