Lycopene supplementation (1, 20 mg/kg BW; 2 times per week for 12 weeks) in nude mice injected with SK-Hep-1 cells managed to significantly reduce MMP-2, VEGF, PCNA, MMP-9, suppress tumor metastasis, mean number of tumors, tumor cross-sectional area while increase nm23-H1. This evidence concerns the gene PCNA and neoplasm.