MAPK8 and neoplasm: Similar observations were described for phlorofucofuroeckol A, which inhibited the phosphorylation of p38, ERK and JNK in LPS-stimulated Raw 264.7 cells [96], and for phloroglucinol, which blocked the phosphorylation of ERK in HT1080 cells [54], both resulting in the suppression of AP-1 activity, another transcription factor involved in the regulation of some pro-inflammatory mediators such as matrix metalloproteinases, a group of enzymes involved in the tissue remodeling during chronic inflammation and cell motility further in a tumor environment.