MMP9 and breast carcinoma: In a different breast cancer cell line (MCF-7 cells), Kim et al. [127] demonstrated that in addition to the inhibition of MMP-9 gene expression, dieckol was also capable stimulate the expression of TIMP-1 and TIMP-2, and even block the expression of VEGF, indicating that this compound may also contribute for the inhibition of tumor vascularization.