Yet, Kang et al. [134] reported that this compound may also exert pro-apoptotic effects on this cell line via an alternative mechanism involving the suppression of insulin-like growth factor-1 receptor (IGF-1R) expression and consequently blocking the PI3K/Akt/mTOR and Ras/ERK-MAPK signaling pathways, both playing key roles in the cell survival, growth and metabolism in colon cancer. The gene discussed is IGF1R; the disease is colonic neoplasm.