These results are consistent with the upregulation of peroxisome proliferator-activated receptor-α (PPAR-α) and ACOX genes, as well as with higher levels of peroxisomal-related proteins in livers of high-fat-fed mice [32,33] and in NAFLD patients [34,35]. The gene discussed is ACOX1; the disease is metabolic dysfunction-associated steatotic liver disease.