For example, MAGEA1 is upregulated in lung cancer, melanoma, and gastric cancer; MAGEA3 is upregulated in breast and lung cancer; MAGEA4 is upregulated in melanoma; MAGEA5 is upregulated in head and neck cancer; and MAGEA9 is upregulated in liver and colon cancer. The gene discussed is MAGEA4; the disease is melanoma.