Moreover, in multiple myeloma, MAGEA3 knockdown increases the levels of the proapoptotic proteins BAX and BIM and the cyclin-dependent kinase (CDK) inhibitor p21; this suggests that MAGEA3 represses apoptosis by regulating BAX, BIM, and p21, and induces cell proliferation [40,41]. Here, MAGEA3 is linked to AL amyloidosis.