Beroukhim et al. [81], studying genome-wide somatic copy-number alterations in a large collection of cancers, found frequent amplifications of the regions surrounding two anti-apoptotic genes, MCL1 and BCL2L1, and deletions containing two pro-apoptotic BCL2 family members, BOK and BBC3. Unfortunately, whole genome sequences of the AML patients studied here are not available to compare it. Here, BBC3 is linked to acute myeloid leukemia.