RUNX1 and acute myeloid leukemia: In the studied samples, the mutations in genes recurrently mutated in AML, e.g., NPM1, DNMT3A, NRAS, RUNX1, ASXL1, ATM, CEBPA seemed to play a pivotal role in leukemogenesis, whereas changes in the BCL2 family gene expression probably played a secondary role.