The expressions of αSMA, COL1A1, COL3A1, IL-6 were higher in TGFβ1-stimulated SSc-Fb than in SSc-Fb, while the expressions of MMP1/TIMP1, MMP3/TIMP2, IL-1β were significantly lower (Figure 2B). The gene discussed is COL1A1; the disease is systemic sclerosis.