CPC EVs were therapeutic in a rat model of doxorubicin/trastuzumab-induced myocardial fibrosis, inflammation, inducible nitric oxide synthase (iNOS), and left ventricular dysfunction and this was due to suppression of genes involved in inflammation, innate immunity, and death by EV miR-146a-5p [205]. The gene discussed is NOS2; the disease is Myocardial fibrosis.