IGF1R and ischemia: In rat MI, remote ischemic conditioning by repeated bilateral hindlimb ischemia/reperfusion resulted in improvement of cardiac function, reduced interstitial fibrosis and reduced oxidant stress and this outcome was suggested to involve systemic delivery from skeletal muscle to cardiomyocytes of exosomes enriched in anti-fibrotic miR-29a and cardioprotective insulin-like growth factor-1 receptor (IGF-1R) [226].