CCl4-induced liver fibrosis in mice resulted in downregulated levels of hepatic mmu_circ_0000623 and when mice were treated with EVs from AD-MSCs enriched in this circular RNA, liver fibrosis was suppressed due to promotion of miR-125/ATG4D-mediated autophagy of damaged cells, including hepatocytes [278]. This evidence concerns the gene ATG4D and Hepatic fibrosis.