PDGFRA and Hepatic fibrosis: One such protein was PDGF receptor alpha (PDGFRα) and its enrichment in EVs was dependent on Src homology region 2 domain-containing phosphatase-2 (SHP2) which binds to Tyr720, and resulted in the ability of the EVs to stimulate HSC migration in vitro and collagen deposition and/or fibrotic gene expression under basal conditions or in carbon tetrachloride (CCl4) or bile duct ligation (BDL) hepatic fibrosis models.