In vitro, activation of LL29 pulmonary fibroblasts was suppressed by BM-MSC EVs and this was due to targeting of frizzled class receptor 6 (FZD6) by EV miR-29b-3p, which was also shown to be required for the inhibition by BM-MSC EVs of bleomycin-induced pulmonary fibrosis in mice [83]. Here, FZD6 is linked to pulmonary fibrosis.