PECAM1 and metabolic dysfunction-associated steatotic liver disease: In experimental NAFLD, the number of EVs in serum or plasma was correlated with cell death, fibrosis and pathological angiogenesis [248] while F3/F4 patients with NAFLD had frequencies of EVs that were, respectively, increased from plasma platelets or CD31+ leukocytes and decreased from endothelial cells or other leukocyte populations [300].