ACTA1 and renal fibrosis: Aldosterone-induced renal fibrosis in db/db mice involved export of EV miR-196b-5p from TEC and its delivery into fibroblasts resulting in downregulation of suppressor of cytokine signaling 2 (SOCS2) expression and enhanced expression of signal transducer and activator of transcription 3 (STAT3), FN, αSMA, or collagen1α1 [115].