Abbreviations: C6, Rat glial cell; HeLa, Immortal human cell line; N1E-115, Mouse neuroblastoma cell line; PC12, Rat pheochromocytoma cell line; sAPP, Soluble derivates of Amyloid-beta precursor protein; SHSY5Y, Human neuroblastoma cell line; SK-N-SH, Human neuroblastoma cell line; SV770, Monkey kidney cell line; U-138, Human astrocytic cell line. The gene discussed is APP; the disease is neuroblastoma.