In addition, lncRNA X-inactive specific transcript (XIST) can be associated with activation of the PI3K/Akt signaling by sponging miR-126, leading to a glucose metabolic switch, cell proliferation, epithelial–mesenchymal transition (EMT) induction and apoptosis resistance, which contribute to glioma progression and malignancy [36]. Here, AKT1 is linked to central nervous system cancer.