MIAT and neoplasm: In addition, lncRNA MIAT upregulation is associated with increased blood–tumor barrier permeability, which is an important requirement for drug delivery to brain tumors, and this increase in blood–tumor barrier permeability was attributed to the sponging of miR-140-3p by MIAT and subsequent activation of ZO-1-associated kinase (ZAK) and nuclear factor kappa B (NF-κB) [58].