MALAT1 and central nervous system cancer: Studies have shown that some lncRNAs such as HOTAIRM1 and colon cancer-associated transcript 2 (CCAT2), associated with tumorigenesis and cancer development, were upregulated in glioma, while other lncRNAs showing tumor-suppressive functions, such as RP11-838N2.4 and MALAT1, were downregulated.