CASP3 and central nervous system cancer: Overexpressed lncRNA CCAT2 in human glioma cell lines might be released in an exosome-dependent manner, and this release leads to the suppression of endothelial cell apoptosis via the downregulation of Bax and caspase 3, which are responsible for angiogenesis induction, glioma development and chemoresistance [40,41].