This study characterized the age-related behavior and motor function in gba+/−//SNCAA53T mice compared to their controls (gba+/−, SNCAA53T, and wt), with the goal of evaluating whether earlier disease manifestations were apparent in gba+/−//SNCAA53T mice, analogous to the prodromal signs observed in patients with GBA1-associated PD. This evidence concerns the gene GBA1 and Parkinson disease.