Increased production of proinflammatory cytokines by macrophages and dendritic cells is an additional factor that can contribute to the progression of Chagas disease and ROS levels are critical for signaling the nuclear factor κB (NF-κB)-dependent expression of proinflammatory cytokines, suggesting that NOX2/ROS produced in macrophages might signal the transcription factors to promote cytokine gene expression, however, the mechanisms are not fully understood yet [78,92,93]. Here, NFKB1 is linked to Chagas disease.