HSPA6 and head and neck squamous cell carcinoma: The transcriptomic data revealed a significant induction of HSR signature genes in both HNSCC spheroid types upon HT and HT + RT, i.e., the expression of some genes of the Hsp70 and Hsp40 families was substantially enhanced, such as HSPA6, HSPA1A, HSPA1B, HSPA1L, as well as DNAJA4, DNAJB1, and DNAJB4 (Figure 4a).