Lipidemia variables and most lipoproteins were significantly associated with phospholipid matrix as well, including TC, TG, LDL-C, HDL-C, Apo A1, Apo B and Apo E. However, the R2 value is less than 0.02 when LDL-C, HDL-C, Apo A1, Apo B and Apo E were included into the model, indicating that the proportion of the variation in the phospholipid matrix explained by these variables is limited. This evidence concerns the gene APOE and hyperlipidemia.