Indeed, in EGFR+ cells resistant to TMZ, SK1 inhibition results in a decrease in cell viability following TMZ treatment; these results are consistent with previous data of literature, both in vitro and in vivo, demonstrating that SK1 inhibition leads to growth arrest of GBM cells [16,28,50,51] and when combined with TMZ treatment results in a reduction of cell viability [48,52]. The gene discussed is EGFR; the disease is glioblastoma.