On the other hand, adiponectin might play an active role in the development of RA as it is able to induce pro-inflammatory responses in cells involved in the pathogenesis of RA, such as fibroblast-like synoviocytes and antibodies against human adiponectin ameliorated rheumatic symptoms in a collagen-induced arthritis mouse model [30,31]. This evidence concerns the gene ADIPOQ and rheumatoid arthritis.