In contrast, MLL4 directly interacts with mutated p53 (p53R273H,P309S) to increase H3K4me1 and histone H3 lysine 27 acetylation (H3K27ac) levels, thus activating the chronic TNFα signaling pathway which accelerates colon cancer invasion [130]. The gene discussed is KMT2D; the disease is colonic neoplasm.