One study also showed that SETD1A regulated breast cancer metastasis by activating MMP expression [113], while another reported that the amplification of SETD1A in mixed ductal and lobular breast cancer (MDLC) regulated the mitotic process by increasing the H3K4me3 marker in the promoter region of mitosis-and-DNA-damage response genes. The gene discussed is SETD1A; the disease is breast carcinoma.