SDHB and metastatic neoplasm: The prevalence of malignancy, defined as the presence of metastases in non-chromaffin tissue such as lymph nodes, liver and bone, varies between 10% and 17% while the presence of germline mutations in the gene encoding succinate dehydrogenase subunit-B (SDHB) is associated with metastatic disease in 40% of cases [7,8,9].