Since PTPN2fl/flxCD11cCre mice showed elevated levels of macrophages, and these macrophages express elevated levels of PTPN2 [20], we hypothesized that macrophages might compensate for the loss of PTPN2 in dendritic cells in our mice and counteract their proinflammatory action upon colitis induction. Here, PTPN2 is linked to colitis.