For example, the introduction of a polar residue (I441T) in the TMS of the Thiamine transporter 1 in Homo sapiens leads to Anemia [33] and the mutation G177R/E in the UbiA prenyltransferase domain-containing protein 1, Homo sapiens, cause the rare Schnyder crystalline corneal dystrophy [34]. Here, SLC19A2 is linked to anemia.