In total, 16 of the 23 patients with multi-locus diagnosis (70%) showed dual molecular diagnosis of hereditary stomatocytosis, most of which were affected by dehydrated hereditary stomatocytosis type 1 (DHS1), and hereditary spherocytosis mainly due to biallelic SPTA1 variants (Table 2). The gene discussed is SPTA1; the disease is dehydrated hereditary stomatocytosis with or without pseudohyperkalemia and/or perinatal edema.