Other main alterations found in cPDAC such as TP53, SMAD4, and CDKN2A seem also frequent in IPMC particularly of the tubular type, with more than 50% of TP53-mutated tumors and about 20–40% of SMAD4 and CDKN2A alterations, but are much less common in colloid carcinomas [18,87]. The gene discussed is SMAD4; the disease is mucinous adenocarcinoma.