GNAS and pancreatic intraductal papillary-mucinous neoplasm: In a meta-analysis reported by Lee et al. [77], which included 11 studies, the pooled prevalence of GNAS mutations in IPMN cases was 56%, irrespective of the presence or absence of an associated carcinoma, with similar mutation rates among the different grades of dysplasia in non-invasive IPMNs.