IL6 and obesity due to melanocortin 4 receptor deficiency: The single nucleotide polymorphisms (SNPs) rs1800797 (–597 G/A), rs1800796 (–572 G/C), and rs1800795 (–174 G/C) that are located in the promoter region of IL6, on the other hand, were associated with obesity and metabolic traits in different ethnic groups [12].