The levels of protein expression of p-p38/p38 ratio, phosphoenolpyruvate carboxykinase (PEPCK), and protein kinase C (PKC)α in the livers were significantly increased in DF group, but not in HF group, which could be significantly reversed by COS (1 and 5%) supplementation (p < 0.05 vs. DF group; Figure 7B–D). The gene discussed is MAPK14; the disease is hydrops fetalis.