F2RL1 and ductal breast carcinoma in situ: In DCIS human samples with invasive component, the presence of myofibroblasts positive for urokinase/plaminogen activator (uPA), plasminogen Activator/Urokinase Receptor (uPAR), MMP13, and/or procoagulant factors, such as tissue factor (TF), thrombin and proteinase-activated receptor 2 (PAR2), is related to progression to IDC [32,33,34].