Another small retrospective study studied the effects of bisphosphonates in patients with EGFR-mutated lung adenocarcinoma and bone metastases (n = 62) and found comparable results (PFS and OS prolonged in the bisphosphonate + EGFR-TKI group compared with the EGFR-TKI group) [54]. Here, EGFR is linked to lung adenocarcinoma.