In an illness-event model, including hs-CRP and e-GFR (see Statistical Analysis section), a 100% decrease in FBF was associated with a 55.5% HR increase in transition 1 (from the baseline status to CV event) and to a more than double increase in transition 2 (from the baseline status to diabetes) (both p < 0.001) (Figure 2). The gene discussed is CRP; the disease is diabetes mellitus.