Among them, most of the cytokines associated with cytokine release syndrome, such as IFNα, IL-1α/1β, IL-6, IL-10, IL-18, and TNFα, have serum concentrations correlated with disease severity, whereas patients with life-threatening COVID-19 demonstrate an additional elevation of other inflammatory factors, including IL-16, IL-21, IL-23, IL-33, IFNγ, C-C motif chemokine ligand (CCL) 11, CCL26, and thrombopoietin [67]. Here, IFNA1 is linked to COVID-19.