Caspase 8 is upregulated and localized to the nucleus in multiple human cancers, correlating with resistance to therapy and poor clinical outcome: it promotes NF-κB-dependent expression of several cytokines, angiogenesis, and tumorigenesis [48], suggesting that the inhibition of Caspase-8 could be an interesting promising regulator of CYLD levels in cancer. The gene discussed is CYLD; the disease is cancer.