CYLD and skin squamous cell carcinoma: Although dysregulation of the CYLD gene was established to be responsible for the development of skin appendage-derived tumors in CYLD syndrome patients [2,3,4], posteriorly, our group and others reported that the catalytic inactivation of CYLD is involved in the development and progression of skin squamous cell carcinomas (SCCs) [10,11,12,13].