IL6 and gastric cancer: Likewise, proinflammatory cytokines such as interleukin (IL)-6, are related to IR in patients with malignancies including GC [63]; proinflammatory cytokines, such IL-6, have been related with inflammatory responses, which contribute to carcinogenesis [64]; the chronic inflammatory process may raise the incidence and mortality of malignancies in patients with T2DM [65]; and, both T2DM and Hp-I increase the risk of GC, accompanied by more severe gastric inflammatory process [66].