In summary, we demonstrate that miR-208b as a marker for cardiac diseases regulates the expression of genes involved in excitation generation and propagation, namely Kcnj5 (GIRK4) and Cacna1c (calcium voltage-gated channel subunit alpha1 C), as well as RNA translocation (Ran) and cardiac hypertrophic response (ROCK2). Here, KCNJ5 is linked to heart disorder.