In regard to localized DNA methylation (Table 3), MDS patients had a significant higher methylation frequency of the P15 (48.5%, 32/66), DAPK (42.4%, 28/66), and KEAP1 (33.3%, 22/66) gene promoters when compared with controls (P15: 11.5%, 3/26; DAPK: 0.0%, 0/26; KEAP1: 11.5%, 3/26). Here, KEAP1 is linked to myelodysplastic syndrome.