The NF-κB inhibitory activity of the three diarylheptanoids (1–3) in PC-3 and LNCaP cells from Western blotting demonstrated that the relative protein expression level of NF-κB was more effectively reduced by the treatment of both PCa cell lines with oregonin (1) and hirsutenone (2), than by treatment with hirsutanonol (3) (Figure 2). Here, NFKB1 is linked to posterior cortical atrophy.