Methylation profiles of mainly CD4+, CD8+ T cells, B cells, monocytes, and cell-free plasma DNA were reported, and the most interesting findings were related to hypomethylation on the IL17A promoter region, which is known to correlate with Th17 cell lineage generation and a decrease in the methylation pattern located in the HLA-DRB1 gene suggesting that the DRB1 haplotype may influence the association observed between the methylation level at DRB1 CpGs and MS risk [41,42,43]. Here, CD4 is linked to myeloid sarcoma.