CTLA4 and neoplasm: As the success of ICB depends on T-cell recognition of tumor antigens, which in turn is determined by a limited number of responsive T-cell clones [137,213], therapies such as anti-CTLA-4 that broaden T-cell recognition of tumor antigens, increase the number of responding clones and synergize with anti-PD-1 in upregulating tumor MHC-I expression [214,215].