Examples include human epidermal growth factor receptors EGFR (HER1) and ERBB2 (HER2) whose overexpression in head and neck, ovarian, cervical, bladder and esophageal cancer (EGFR), or breast and ovarian cancer (HER2) is associated with poor prognosis [145,146,147]. The gene discussed is ERBB2; the disease is ovarian cancer.