Circulating NK cells exhibit a diverse expression pattern of activating and inhibitory receptors, chemokine receptors, cytokines and cytolytic molecules [236], allowing NK cells to collectively display tolerance towards cellular targets expressing normal levels of MHC-I molecules while eliminating stressed cells that have down-regulated MHC-I and up-regulated activating ligands, such as MHC-I-related chain A (MICA) and MICB proteins in cancer [237,238] (Figure 2A). The gene discussed is MICB; the disease is cancer.