For example, somatic mutations at hot spot positions in cancer driver genes —which are relatively common in tumors—are associated with low MHC binding ability; such mutations tend to occur in protein regions containing amino acid residues with weak MHC binding properties (KRAS G12C/D/V and G13D, TP53 R175H and H179R), or the driver substitution itself lowers MHC binding (BRAFV600E, TP53 Y220C) [194]. Here, HLA-C is linked to cancer.