For example, vitiligo, ocular toxicity and hearing loss due to destruction of normal melanocytes were observed in some melanoma patients after adoptive transfer of ex vivo expanded T-cell products recognizing melanocytic antigens [152,153,154,155,156], in particular after adoptive transfer of genetically engineered T cells with high affinity for MART-1 or gp100 [121]. Here, PMEL is linked to melanoma.