Various investigations evidently support the involvement of neuroinflammation in PD progression, which is primarily adjudicated by microglia activation, being a source of superoxide it aids in the development of oxidative stress conditions in the neuronal tissue [206,207] and produces tumor necrosis factor-alpha (TNF-α) and glutamate, which in turn supports neurodegeneration. The gene discussed is TNF; the disease is Parkinson disease.