CACNA1C and Parkinson disease: In juvenile SNpc dopaminergic neurons, calcium channel, voltage dependent, L-type, α1C-subunit (Cav1.2) is present in active form, whereas during aging it is used by dopaminergic neurons to promote calcium influx, thereby aiding rhythmic pacemaker activity, which is significant in the maintenance of the striatal dopaminergic levels as highlighted by the role of Cav1.2 in regulation of dopaminergic firing activity in the ventral tegmental area in PD mouse models [193,194,195].