Indeed, hypertension, one of the major risk factors for strokes, induces a structural narrowing of the cerebral arterial lumen (thus reducing blood perfusion in case of a stroke) that only antihypertensive treatments targeting RAS and AT1 stimulation (ACE inhibitors and/or ARBs) are able to prevent [17,28,29]. The gene discussed is AGTR1; the disease is Hypertension.