Due to the strong association of BAP1 mutations with M3 in UM, differences in gene expression and prognosis could be a result of differential chromosome 3 status independent of BAP1. The options for investigating the exact role of BAP1 independent of M3 as a driver of tumor aggressiveness in UM using genomic and transcriptomic patient data are limited because of the lack of data from M3 tumors without BAP1 mutations. The gene discussed is BAP1; the disease is neoplasm.