BAP1 and intrahepatic cholangiocarcinoma: Similar effects were observed in a study by Chen and colleagues, where reconstitution of wild-type BAP1 in a BAP1-mutated intrahepatic cholangiocarcinoma (ICC) cell line led to decreased cell proliferation, cell cycle progression and invasion, while knockdown of BAP1 in a BAP1-wild type ICC cell line showed the opposite effect [36].