At the neuropathological level, Alzheimer’s disease is mainly defined by an extracellular accumulation of amyloid-β (Aβ) plaques and reactive gliosis and cellular tau-containing neurofibrillary tangles (NFTs) accompanied by synaptic dysfunction and cholinergic-dependent progressive memory decline [2]. Here, MAPT is linked to early-onset autosomal dominant Alzheimer disease.