MMP2 and glioblastoma: Monocyte-derived macrophages challenged with a variety of stimuli including chemokines show differential packing of EV-miRNAs [77] that induce integrin expression in endothelial cells [78], in adventitia vascular smooth muscle cells they elevate matrix metalloproteinases-2 (MMP-2) through JNK and p38 to promote aneurysms [79] and induce proneural-to-mesenchymal transition (PMT) in glioblastoma by transfer of EV- miR-27a-3p, miR-22-3p, and miR-221-3p [80].