The accumulation of misfolded α-synuclein (SNCA or α-Syn) is implicated in several neurodegenerative diseases known as synucleinopathies, which include Parkinson’s disease (PD), dementia with Lewy bodies (DLB), and multiple-system atrophy (MSA) [1,2,3]. The gene discussed is SNCA; the disease is multiple system atrophy.