Kobayashi et al. confirmed those effects within an osteoarthritis cartilage explant model in which they used the IL-1RA antagonist anakinra to block the IL-1β biologic activity, thus demonstrating the implication of this cytokine in the production of MMPs (MMP-1, MMP-3 and MMP-13) [12]. Here, MMP13 is linked to osteoarthritis.