TNF and rheumatoid arthritis: Other authors have shown that the simultaneous intra-articular injections of this miRNA with the miR-140-3p ameliorates the RA features [74] and these results are corroborated by the fact that simultaneous overexpression of miR-140-5p and miR-146a in osteoarthritic chondrocytes reduced NF-κb phosphorylation, as well as the expression of TLR4, IL-1β, IL-6, and TNF-α [75].