TNF and rheumatoid arthritis: The study reporting the benefits of using intra-articular injections of the anti-TNF infliximab, loaded onto thermosensitive hydrogel to decrease pro-inflammatory cytokines within the synovial fluids of a rabbit model of RA induced by ovalbumin and complete Freund’s adjuvant, is another example illustrating the interplay between TNF-α and IL-1β in vivo [41].