Kheradmand et al. and Moghaddam et al. showed that HstP and HstN upregulate antioxidative mechanisms; for example, catalase (CAT), superoxide dismutase (SOD), glutathione reductase (GRx), and glutathione (GSH) levels were upregulated in a rat model of AD [31,56]. The gene discussed is SOD1; the disease is Alzheimer disease.