Compound C, an inhibitor of AMPK, suppressed the activity of mTOR, suggesting that mTOR is downstream of AMPK in the regulation of autophagy by exogenous H2S. Compound C and AMPK-siRNA both inhibited H2S-promoted autophagy in HG-induced H9C2 cells, increased apoptosis and aggravated cell injury, indicating that exogenous H2S alleviated DCM by activating autophagy through activating the AMPK/mTOR signaling pathway [59]. Here, MTOR is linked to familial dilated cardiomyopathy.