In light of these results, we further focused on deregulated miRNAs and their putative interactions with B-cell specific transcription factors SPI1 and ELF-1 attenuated in cHL [5,16] and also the NF-ĸB inhibitor TNFAIP3 recurrently inactivated in this lymphoma [17]. The gene discussed is SPI1; the disease is classic Hodgkin lymphoma.